Zebrafish are a powerful animal model for small molecule screening.Small molecule treatments Antiseptic of zebrafish embryos usually require that the chorion, an acellular envelope enclosing the embryo, is removed in order for chemical compounds to access the embryo from the bath medium.For large-scale studies requiring hundreds of embryos, manual
Ubiquitination is a crucial Leucine post-translational modification process that can degrade proteins within cells and plays a vital role in maintaining protein homeostasis and abundance.Deubiquitinating enzymes (DUBs) are important proteases in the ubiquitin system.They reverse the ubiquitination process by cleaving protein chains and recycling ub
Introduction.A proper, varied diet is indispensable to ensure the correct growth and development of children.Nutrition of this period of life also affects health status in adulthood.Evaluation of nutritional status in this vulnerable group can provide significant information, some of which will be applicable to the entire community.Findings can pro
Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection.Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.We evaluated the hypothesis that TFR suppress HIV replication in TFH using a well-established model of ex vivo HIV i